How SAM-e Reduces Fibro Symptoms


What is SAM-e?

SAM-e is a chemical compound that occurs naturally in the body. It’s formed by a combination of two molecules, each crucial for your body’s normal functioning: methionine, an amino acid that serves as a building block for many proteins necessary for bodily function; and ATP, the main energy source for all the cells in your body.

Note that despite the fact that SAM-e normally is produced naturally by the body, people with methionine, folate (vitamin B9), and/or vitamin B12 deficiencies almost always develop a deficiency in SAM-e as well. Furthermore, multiple studies have shown that people with fibromyalgia demonstrate severe deficiencies in these and other crucial chemical compounds. This means that if you’re suffering from fibromyalgia, it’s extremely likely that your body is deficient in SAM-e; and because SAM-e is generally widespread in the body and critical for over 100 complex biochemical reactions, this deficiency is causing your body to perform less than optimally—even causing or worsening your fibromyalgia symptoms

How does SAM-e work to reduce fibromyalgia symptoms?

SAM-e’s exact mechanism of action isn’t fully understood. Still, due to its performance in clinical trials and in treated patients, doctors and researchers have come up with several likely hypotheses.

One hypothesis is that SAM-e “donates” a part of its chemical structure to your central nervous system (CNS) receptors in a chemical reaction. This reaction increases the brain’s production of certain neurotransmitters associated with wellbeing and mood stability, including serotonin, dopamine, and norepinephrine. There are multiple clinical studies documenting the effectiveness of SAM-e as an antidepressant—many people find it to be as or more effective than standard prescription antidepressants (including tricyclic antidepressants and SSRIs), but without their the unpleasant side effects. Note that while I’m not trying to perpetuate the myth that fibromyalgia is caused by (or is no more than) depression, there’s good evidence that improved mental/psychological health can reduce the frequency and intensity of fibromyalgia symptoms.

Other researchers have noted that SAM-e demonstrates the same anti-inflammatory and pain-relief effects of NSAIDS (non-steroidal anti-inflammatory drugs) such as Advil, Tylenol, and Aspirin—but without their deadly side effects! Finally, there’s clinical evidence that people with fibromyalgia exhibit extensive mitochondrial damage throughout the body (especially in the muscles and spinal cord). Because ATP production takes place in the mitochondria, this means that people with fibromyalgia have less ATP—or energy—in their muscles, causing fibro’s agonizing muscle pain and stiffness.

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